Chapter II

Neoplasms
(C00-D48)

Neoplasms of uncertain or unknown behaviour
(D37-D48)

Note: Categories D37-D48 classify by site neoplasms of uncertain or unknown behaviour, i.e., there is doubt whether the neoplasm is malignant or benign. Such neoplasms are assigned behaviour code /1 in the classification of the morphology of neoplasms.

D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
D37.0 Lip, oral cavity and pharynx
Aryepiglottic fold:
· NOS
· hypopharyngeal aspect
· marginal zone
Major and minor salivary glands
Vermilion border of lip
Excludes: aryepiglottic fold, laryngeal aspect ( D38.0 )
epiglottis:
· NOS ( D38.0 )
· suprahyoid portion ( D38.0 )
skin of lip ( D48.5 )
D37.1 Stomach
D37.2 Small intestine
D37.3 Appendix
D37.4 Colon
D37.5 Rectum
Rectosigmoid junction
D37.6 Liver, gallbladder and bile ducts
Ampulla of Vater
D37.7 Other digestive organs
Anal:
· canal
· sphincter
Anus NOS
Intestine NOS
Oesophagus
Pancreas
Excludes: anal:
· margin ( D48.5 )
· skin ( D48.5 )
perianal skin ( D48.5 )
D37.9 Digestive organ, unspecified

D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
Excludes: heart ( D48.7 )
D38.0 Larynx
Aryepiglottic fold, laryngeal aspect
Epiglottis (suprahyoid portion)
Excludes: aryepiglottic fold:
· NOS ( D37.0 )
· hypopharyngeal aspect ( D37.0 )
· marginal zone ( D37.0 )
D38.1 Trachea, bronchus and lung
D38.2 Pleura
D38.3 Mediastinum
D38.4 Thymus
D38.5 Other respiratory organs
Accessory sinuses
Cartilage of nose
Middle ear
Nasal cavities
Excludes: ear (external)(skin) ( D48.5 )
nose:
· NOS ( D48.7 )
· skin ( D48.5 )
D38.6 Respiratory organ, unspecified

D39 Neoplasm of uncertain or unknown behaviour of female genital organs
D39.0 Uterus
D39.1 Ovary
D39.2 Placenta
Chorioadenoma destruens
Hydatidiform mole:
· invasive
· malignant
Excludes: hydatidiform mole NOS ( O01.9 )
D39.7 Other female genital organs
Skin of female genital organs
D39.9 Female genital organ, unspecified

D40 Neoplasm of uncertain or unknown behaviour of male genital organs
D40.0 Prostate
D40.1 Testis
D40.7 Other male genital organs
Skin of male genital organs
D40.9 Male genital organ, unspecified

D41 Neoplasm of uncertain or unknown behaviour of urinary organs
D41.0 Kidney
Excludes: renal pelvis ( D41.1 )
D41.1 Renal pelvis
D41.2 Ureter
D41.3 Urethra
D41.4 Bladder
D41.7 Other urinary organs
D41.9 Urinary organ, unspecified

D42 Neoplasm of uncertain or unknown behaviour of meninges
D42.0 Cerebral meninges
D42.1 Spinal meninges
D42.9 Meninges, unspecified

D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
Excludes: peripheral nerves and autonomic nervous system ( D48.2 )
D43.0 Brain, supratentorial
Cerebral ventricle
Cerebrum
Frontal
Occipital
Parietal
Temporal
}
}
}
}
lobe
Excludes: fourth ventricle ( D43.1 )
D43.1 Brain, infratentorial
Brain stem
Cerebellum
Fourth ventricle
D43.2 Brain, unspecified
D43.3 Cranial nerves
D43.4 Spinal cord
D43.7 Other parts of central nervous system
D43.9 Central nervous system, unspecified
Nervous system (central) NOS

D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
Excludes: endocrine pancreas ( D37.7 )
ovary ( D39.1 )
testis ( D40.1 )
thymus ( D38.4 )
D44.0 Thyroid gland
D44.1 Adrenal gland
D44.2 Parathyroid gland
D44.3 Pituitary gland
D44.4 Craniopharyngeal duct
D44.5 Pineal gland
D44.6 Carotid body
D44.7 Aortic body and other paraganglia
D44.8 Pluriglandular involvement
Multiple endocrine adenomatosis
D44.9 Endocrine gland, unspecified

D45 Polycythaemia vera
Morphology code M9950 with behaviour code /1

D46 Myelodysplastic syndromes
Includes: morphology code M998 with behaviour code /1
D46.0 Refractory anaemia without sideroblasts, so stated
D46.1 Refractory anaemia with sideroblasts
D46.2 Refractory anaemia with excess of blasts
D46.3 Refractory anaemia with excess of blasts with transformation
D46.4 Refractory anaemia, unspecified
D46.7 Other myelodysplastic syndromes
D46.9 Myelodysplastic syndrome, unspecified
Myelodysplasia NOS
Preleukaemia (syndrome) NOS

D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
Includes: morphology codes M974, M976, M996-M997 with behaviour code /1
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
Mast cell tumour NOS
Mastocytoma NOS
Excludes: mastocytosis (cutaneous) ( Q82.2 )
D47.1 Chronic myeloproliferative disease
Myelofibrosis (with myeloid metaplasia)
Myeloproliferative disease, unspecified
Myelosclerosis (megakaryocytic) with myeloid metaplasia
D47.2 Monoclonal gammopathy
D47.3 Essential (haemorrhagic) thrombocythaemia
Idiopathic haemorrhagic thrombocythaemia
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
Lymphoproliferative disease NOS

D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
Excludes: neurofibromatosis (nonmalignant) ( Q85.0 )
D48.0 Bone and articular cartilage
Excludes: cartilage of:
· ear ( D48.1 )
· larynx ( D38.0 )
· nose ( D38.5 )
connective tissue of eyelid ( D48.1 )
synovia ( D48.1 )
D48.1 Connective and other soft tissue
Connective tissue of:
· ear
· eyelid
Excludes: cartilage (of):
· articular ( D48.0 )
· larynx ( D38.0 )
· nose ( D38.5 )
connective tissue of breast ( D48.6 )
D48.2 Peripheral nerves and autonomic nervous system
Excludes: peripheral nerves of orbit ( D48.7 )
D48.3 Retroperitoneum
D48.4 Peritoneum
D48.5 Skin
Anal:
· margin
· skin
Perianal skin
Skin of breast
Excludes: anus NOS ( D37.7 )
skin of genital organs ( D39.7 , D40.7 )
vermilion border of lip ( D37.0 )
D48.6 Breast
Connective tissue of breast
Cystosarcoma phyllodes
Excludes: skin of breast ( D48.5 )
D48.7 Other specified sites
Eye
Heart
Peripheral nerves of orbit
Excludes: connective tissue ( D48.1 )
skin of eyelid ( D48.5 )
D48.9 Neoplasm of uncertain or unknown behaviour, unspecified
"Growth" NOS
Neoplasm NOS
New growth NOS
Tumour NOS